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W S X g R t ` \ W x } ` v C } b v 摜 ܂Ƃ } b v ʃ} ` v C } b v 摜 ꗗ Overpass;. Welcome to AEG AEG was founded in Germany over a century ago on a simple philosophy everything it designs should be perfect in both form and function. Interestingly, in contrast to canonical nucleosomes that negatively supercoil DNA, the CENPTWSX complex induces positive DNA supercoils We found that the DNAbinding regions in CENPT or CENPW, but not CENPS or CENPX, are required for this positive supercoiling activity and the kinetochore targeting of the CENPTWSX complex.

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454 Followers, 434 Following, 18 Posts See Instagram photos and videos from _Hari sanker_ (@_t_w_o_n_t_y_s_i_x_).  · The CENPTWSX heterotetramer plays a key role in centromere function, but similar nucleosomelike structures may also be found at other genomic locations Indeed, the CENPSX complex has been shown to interact with FANCM at DNA damage sites (Yan et al, 10, Singh et al, 10). Here, we demonstrate that the centromeric histonefoldcontaining CENPTW and CENPSX complexes coassemble to form a stable CENPTWSX heterotetramer Highresolution structural analysis of the individual complexes and the heterotetramer reveals similarity to other histone foldcontaining complexes including canonical histones within a nucleosome.

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